Effect of Herbal Hypoglycemics on Oxidative Stress and Antioxidant Status in Diabetic Rats

Sunila Vasi1, Anoop Austin2, *
1 Department of Chemistry, Arignar Anna College, Aralvaymoli, Nagercoil, India
2 Rumi Herbals R&D Centre, 6/15, Ohri Salai, Mugappair East, Chennai 600 037, India

© Vasi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Rumi Herbals R&D Centre, 6/15, Ohri Salai, Mugappair East, Chennai 600 037, India; Tel: 044 26358315; Fax: 044 26180269; E-mail:


Antioxidative potential of four commonly used Indian medicinal plants Gymnema sylvestre, Salacia reticulata, Cassia auriculata and Eugenia jambolanum was screened for its antidiabetic activity by streptozotocin induced diabetic rats. Lipid peroxide levels were also measured in normal, diabetic and treated animals. Malondialdehyde (MDA) levels were significantly higher and antioxidant activity was found low in diabetic groups as compared to the control groups, and significant alteration in both the MDA levels and antioxidant activity was also observed when the above herbal hypoglycemic agents were given to diabetic rats. The results confirm that the herbs were not only useful in controlling the lipid peroxide levels but are also helpful in further strengthening the antioxidant potential.

Keywords: Free radicals, diabetes mellitus, antioxidants.