RESEARCH ARTICLE


Spontaneously Diabetic Torii Leprfa (SDT Fatty) Rat: A Novel Model of Obese Type 2 Diabetes



Sumiaki Fukuda*, Katsuhiro Miyajima, Tomohiko Sasase, Takeshi Ohta
Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.

Article Information


Identifiers and Pagination:

Year: 2011
Volume: 4
First Page: 30
Last Page: 36
Publisher Id: TODIAJ-4-30
DOI: 10.2174/1876524601104010030

Article History:

Received Date: 27/04/2010
Revision Received Date: 24/12/2010
Acceptance Date: 15/01/2011
Electronic publication date: 28/3/2011
Collection year: 2011

© Fukuda et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan. E-mail: takeshi.ota@jt.com


Abstract

Diabetic animal models play critical roles in the elucidation of the mechanisms of diabetes mellitus and the complications, and in the development of novel drugs as treatments. Spontaneously Diabetic Torii Leprfa (SDT fatty) rat, established by introducing the fa allele of the Zucker fatty rat into SDT rat genome, is a new model of obese type 2 diabetes. We have investigated the characteristics of SDT fatty rats. Both male and female SDT fatty rats show overt obesity, and hyperglycemia and hyperlipidemia are observed at a young age as compared with SDT rats. With early incidence of diabetes mellitus, diabetic complications in SDT fatty rats were seen at younger ages than those in the SDT rats. Furthermore, we evaluated the pharmacological effects of anti-diabetic drugs, such as metformin, pioglitazone, and dipeptidyl peptidase-4 inhibitor on SDT fatty rats. SDT fatty rat is a useful model for analysis of metabolic disease and the evaluation of drugs related to metabolic disease.