RESEARCH ARTICLE


Diabetic Ocular Complications in the SDT Rat



Akihiro Kakehashi*
Department of Ophthalmology, Saitama Medical Center, Jichi Medical University, Saitama, 330-8503, Japan.

Article Information


Identifiers and Pagination:

Year: 2011
Volume: 4
First Page: 37
Last Page: 40
Publisher Id: TODIAJ-4-37
DOI: 10.2174/1876524601104010037

Article History:

Received Date: 23/04/2010
Revision Received Date: 11/05/2010
Acceptance Date: 15/01/2011
Electronic publication date: 28/3/2011
Collection year: 2011

© Kakehashi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Ophthalmology, Saitama Medical Center, Jichi Medical University, Saitama, 330-8503, Japan. E-mail: takeshi.ota@jt.com


Abstract

The purpose of the current article was to describe the diabetic ocular complications in a new animal model of diabetes, the Spontaneously Diabetic Torii (SDT) rat. Three major diabetic ocular complications, cataract, diabetic retinopathy (DR), and neovascular glaucoma develop in the SDT rat. The cataract develops to maturity, and DR develops to the advanced stage. Large retinal folds mimicking a tractional retinal detachment with extensive fluorescein leakage around the optic disc are the most characteristic finding of DR in this rat. In some rats, neovascular glaucoma develops with a massive hemorrhage in the anterior chamber associated with neovascular fibrous membranes around the iris. Although there are some differences in the diabetic ocular complications between SDT rats and human patients with diabetes, the SDT rat model is useful for studying diabetic ocular complications.