RESEARCH ARTICLE
Diabetic Nephropathy in Spontaneously Diabetic Torii (SDT) Rats
Takeshi Ohta*, Tomohiko Sasase
Japan Tobacco, Inc. Central Pharmaceutical Research Institute 1-1, Murasaki-cho, Takatsuki, Osaka, 569-1125, Japan.
Article Information
Identifiers and Pagination:
Year: 2011Volume: 4
First Page: 45
Last Page: 49
Publisher Id: TODIAJ-4-45
DOI: 10.2174/1876524601104010045
Article History:
Received Date: 27/04/2010Revision Received Date: 11/12/2010
Acceptance Date: 15/01/2011
Electronic publication date: 28/3/2011
Collection year: 2011
© Ohta et al.
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Diabetic nephropathy is a serious complication of diabetes mellitus, making it essential to develop animal models of diabetic complications to simulate the pathogenesis in humans. We monitored pathobiochemical parameters and histopathological findings of kidneys in male Spontaneously Diabetic Torii (SDT) rats. Renal-related parameters in SDT rats have deteriorated with the progress of diabetes mellitus, and histopathological changes in the renal tubules and the glomeruli were observed with aging. Glycemic control in SDT rats prevented the development of renal lesions. The features of SDT rat indicate its usefulness as an animal model for investigating diabetic nephropathy.
