RESEARCH ARTICLE
Diabetic Neuropathy in Spontaneously Diabetic Torii Rat
Tomohiko Sasase*, Takeshi Ohta
Article Information
Identifiers and Pagination:
Year: 2011Volume: 4
First Page: 50
Last Page: 54
Publisher Id: TODIAJ-4-50
DOI: 10.2174/1876524601104010050
Article History:
Received Date: 27/04/2010Revision Received Date: 11/12/2010
Acceptance Date: 15/01/2011
Electronic publication date: 28/3/2011
Collection year: 2011
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
To aid in the study of diabetes and its complications, many diabetic animal models have been reported. Although most diabetic patients suffer type 2 diabetes, studies using type 2 diabetic animal models have been carried out less frequently. Spontaneously Diabetic Torii (SDT) rat, a non-obese type 2 diabetes model, shows neuropathies and severe ocular complications. Decreased nerve conduction velocity and thermal hypoalgesia were improved by insulin treatment, indicating that the peripheral neuropathies in SDT rats are caused by sustained hyperglycemia. Autonomic nerve dysfunctions such as decreased coefficients of variance of R-R intervals (CVR-R) in electrocardiogram, functional gastrointestinal disorders, and voiding dysfunction are also observed in SDT rats. Therefore, SDT rat is a useful diabetic animal model for studies of diabetic neuropathies in type 2 diabetes and development of new drugs and therapies for diabetic neuropathies.