RESEARCH ARTICLE


Effect of Oophorectomy and Estrogen Administration on Diabetic Pathogenesis in Female Spontaneously Diabetic Torii Rats



Masami Shinohara*, 1, Toshihiro Oikawa2, Kahei Sato3, Yasunori Kanazawa4
1 CLEA Japan, Inc., Planning and Development Section, 1-2-7, Higashiyama, Meguro-ku, Tokyo 153-8533, Japan.
2 Department of Pharmacovigilance, Torii Pharmaceutical Co. Ltd., 3-4-1, Nihonbashi-Honcho, Chuo-ku, Tokyo 103- 8439, Japan
3 Department of Applied Biological Science, College of Bioresource Sciences, Nihon University, Fujisawa 252-0813, Japan.
4 Jichi Medical University, 3311-1 Yakushiji, Minami-Kawachi, Tochigi 329-0498, Japan.

Article Information


Identifiers and Pagination:

Year: 2011
Volume: 4
First Page: 96
Last Page: 100
Publisher Id: TODIAJ-4-96
DOI: 10.2174/1876524601104010096

Article History:

Received Date: 15/05/2010
Revision Received Date: 30/10/2010
Acceptance Date: 16/01/2011
Electronic publication date: 28/3/2011
Collection year: 2011

© Shinohara et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the CLEA Japan, Inc., Planning and Development Section, 1-2-7, Higashiyama, Meguro-ku, Tokyo 153-8533, Japan. Tel: +81-3-5704-7272; Fax: +81-3-3791-2859; E-mails: shinohara-m@clea-japan.com, aaron@asahi-ns.email.ne.jp


Abstract

In order to examine the effect of sex hormones on diabetic pathogenesis in female Spontaneously Diabetic Torii (SDT) rats, we performed oophorectomy on female SDT rats, administered female hormones after the oophorectomy, and measured body weight changes, plasma glucose concentration, and pancreatic histopathology. At 26 weeks of age, the body weight was significantly heavier in the oophorectomized group and significantly lighter in the estradiol benzoate (EB) administration group than in the sham-operated control group. Although glucose concentration did not significantly change in the oophorectomized group, it was significantly lower in the EB administration group than in both control and the oophorectomized group. Severe histopathological change was observed in the oophoretomized group but not in the EB administration group. Thus, EB blocked weight gain and pancreatic islet change that was induced by oophoretomy and it also lowered glucose concentration. These results suggest that estrogen plays a preventive role for diabetic pathogenesis in female SDT rats.

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