Type 2 Diabetes Study, Introduction and Perspective



Da-Yong Lu1, *, Jin-Yu Che1, Nagendra Sastry Yarla2, Hong Zhu3, Ting-Ren Lu1, Bin Xu4, Swathi Putta5
1 Shanghai University, Shanghai 200444, P. R. China
2 Divisions of Biochemistry & Chemistry, City University of New York School of Medicine, 160 Convent Avenue, New York, NY 10031, USA
3 College of Pharmaceutical Science, Zhejiang University, Hangzhou, P. R. China
4 Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P. R. China
5 College of Pharmaceutical Science, Andhra University, Visakhapatnam, AP, India


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© 2018 Lu et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Shanghai University, Shanghai 200444, P. R. China, E-mail; ludayong@shu.edu.cn


Abstract

Background:

The prevalence of Type 2 Diabetes Mellitus (T2DM) continues to rise globally. The T2DM prevalence is not only in developing countries, but also in developed countries now. Correspondingly, the therapeutics of T2DM calls for a change (higher efficiency) due to growing number of patients and increasing economic burdens globally. Entering into this millennium, both piecemeal pathways (idea driven) and exponential growth of human genomic study are developing quickly. Genetypic-phenotypic translation, modern diagnostics, pharmacology, drug developments, traditional Chinese medicine, personalized medicine and so on are promising disciplines for this change. The clinical anti-diabetic therapeutics, pathogenesis, drug development pipelines are especially highlighted.

Conclusion:

In summary, a general landscape and principle of T2DM is provided.

Keywords: Anti-diabetic therapy, Insulin-derivatives, Natural chemotherapeutic drugs, Diabetes-induced complication, Traditional Chinese Medicine, Diabetic pathology, Herbal medicine.